Isolated bone erosions likely not clinically significant

Isolated del(5q) in Patients Following Therapies for Various Malignancies May Not All Be Clinically Significant.

OBJECTIVES Deletion 5q is a common chromosomal abnormality in both de novo and therapy-related myeloid neoplasms (t-MNs). The detection of isolated del(5q) in patients following therapies for various malignancies raises serious concern for an emerging t-MN. METHODS We identified 25 patients who developed isolated del(5q) following cytotoxic therapy (n = 21) or tyrosine kinase inhibitor (TKI; ...

Are isolated distal deep-vein thromboses clinically significant?

10.2217/14750708.5.2.151 © 2 The authors consider isolated distal deep-vein thrombosis (DVT) to be significant and recommend treating isolated symptomatic distal DVT in the same way as proximal lower-limb DVT. There is no guidance for the treatment of asymptomatic isolated distal DVT; however, certain triggers could be used to guide therapy. Our policy is as follows: all patients with distal DV...

Erosions rare without clinically detectable inflammation.

Low bone mineral density with tenofovir: does statistically significant mean clinically significant?

Adults with human immunodeficiency (HIV) infection appear to have a greater prevalence of low bone mineral density (BMD) and of fractures than do adults without HIV infection [1,2]. HIV infection itself may contribute to this greater prevalence. HIV induces inflammation (a known association with accelerated BMD loss), and low BMD has been reported in individuals with untreated HIV infection [1,...

Local bone erosions in rheumatoid arthritis

Bone erosion is a hallmark of rheumatoid arthritis. Recent evidence from experimental arthritis suggests that osteoclasts are essential for the formation of local bone erosions. Two essential regulators of osteoclastogenesis have recently been described: the receptor-activator of nuclear factor kappa B ligand, which promotes osteoclast maturation, and osteoprotegerin (OPG), which blocks osteocl...